Unexpected formation of an estrone derivative from androsta-1,4-diene-3,17-dione

被引：0

作者：

Görlitzer, K

Bonnekessel, C

Jones, PG

Kaufmann, G

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Pharmaceut Chem, D-38106 Braunschweig, Germany

[2] Tech Univ Carolo Wilhelmina Braunschweig, Inst Anorgan & Analyt Chem, D-38106 Braunschweig, Germany

[3] Jenapharm GmbH & Co KG, Jena, Germany

来源：

PHARMAZIE | 2002年 / 57卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Reaction of androsta-1,4-diene-3,17-dione (1) with pyrrolidine and p-toluenesulfonic acid in toluene gives 3-pyrrolidinoestra-1,3,5(10)-triene-6,17-dione (7) in poor yield, whose structure is shown by X-ray analysis. Compared With H-3-estradiol, compound 7 shows only a weak receptor binding activity tested in an in vitro screening using rabbit uterus cytosol.

引用

页码：808 / 810

页数：3

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