Unexpected formation of an estrone derivative from androsta-1,4-diene-3,17-dione

被引：0
|
作者：
Görlitzer, K
Bonnekessel, C
Jones, PG
Kaufmann, G
机构：
[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Pharmaceut Chem, D-38106 Braunschweig, Germany
[2] Tech Univ Carolo Wilhelmina Braunschweig, Inst Anorgan & Analyt Chem, D-38106 Braunschweig, Germany
[3] Jenapharm GmbH & Co KG, Jena, Germany
来源：
PHARMAZIE | 2002年 / 57卷 / 12期
关键词：
D O I：
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Reaction of androsta-1,4-diene-3,17-dione (1) with pyrrolidine and p-toluenesulfonic acid in toluene gives 3-pyrrolidinoestra-1,3,5(10)-triene-6,17-dione (7) in poor yield, whose structure is shown by X-ray analysis. Compared With H-3-estradiol, compound 7 shows only a weak receptor binding activity tested in an in vitro screening using rabbit uterus cytosol.
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页码：808 / 810
页数：3
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