The Epigenetics of Aging in Invertebrates

被引：20
作者：
Yu, Guixiang [1 ]
Wu, Qi [1 ]
Gao, Yue [1 ]
Chen, Meiling [1 ]
Yang, Mingyao [1 ,2 ]
机构：
[1] Sichuan Agr Univ, Inst Anim Genet & Breeding, Chengdu 611130, Sichuan, Peoples R China
[2] Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu 611130, Sichuan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 18期
基金：
中国国家自然科学基金;
关键词：
aging; crosstalk; DNA methylation; histone modification; ncRNA; LIFE-SPAN EXTENSION; C.-ELEGANS; HISTONE ACETYLATION; DNA METHYLATION; CAENORHABDITIS-ELEGANS; SACCHAROMYCES-CEREVISIAE; GENE-EXPRESSION; NONCODING RNA; DROSOPHILA; LONGEVITY;
D O I：
10.3390/ijms20184535
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging is an unstoppable process coupled to the loss of physiological function and increased susceptibility to diseases. Epigenetic alteration is one of the hallmarks of aging, which involves changes in DNA methylation patterns, post-translational modification of histones, chromatin remodeling and non-coding RNA interference. Invertebrate model organisms, such as Drosophila melanogaster and Caenorhabditis elegans, have been used to investigate the biological mechanisms of aging because they show, evolutionarily, the conservation of many aspects of aging. In this review, we focus on recent advances in the epigenetic changes of aging with invertebrate models, providing insight into the relationship between epigenetic dynamics and aging.
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页数：17
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