A new paraneoplastic encephalomyelitis autoantibody reactive with the axon initial segment

被引：9
|
作者：
Shams'ili, Setareh [1 ]
de Leeuw, Bertie [1 ]
Hulsenboom, Esther [1 ]
Jaarsma, Dick [2 ]
Smitt, Peter Sillevis [1 ]
机构：
[1] Erasmus Univ, Med Ctr, Dept Neurol, NL-3000 DR Rotterdam, Netherlands
[2] Erasmus Univ, Med Ctr, Dept Neurosci, NL-3000 DR Rotterdam, Netherlands
来源：
NEUROSCIENCE LETTERS | 2009年 / 467卷 / 02期
关键词：
Paraneoplastic encephalomyelitis; Axon initial segment; UBE2E1; UbcH6; beta IV spectrin; BETA-IV SPECTRIN; RANVIER; PROTEIN; CANCER; SYSTEM; NODES;
D O I：
10.1016/j.neulet.2009.10.031
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Serum from a patient with paraneoplastic encephalomyelitis (PEM) and small cell lung cancer (SCLC) showed high titer immunohistochemical staining of the axon initial segment (AIS) on rat and human brain sections. EM studies showed that the antigen was localized in close proximity of the microtubules in the AIS. Double labeling experiments and absence of staining at the nodes of Ranvier excluded the previously identified beta IV spectrin as autoantigen. Screening a rat hippocampal cDNA library resulted in the isolation of ubiquitin-conjugating enzyme E2E1 (UBE2E1). However, blocking and elution experiments excluded UBE2E1 as the AIS autoantigen. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：169 / 172
页数：4
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