Pancreatitis-associated protein: From a lectin to an anti-inflammatory cytokine

被引：50
作者：
Closa, Daniel
Motoo, Yoshiharu
Iovanna, Juan L.
机构：
[1] CSIC, IIBB, Dept Expt Pathol, IDIBAPS, Barcelona 08036, Spain
[2] Kanazawa Med Univ, Dept Med Oncol, Kanazawa, Ishikawa, Japan
[3] INSERM, U624, F-13258 Marseille, France
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2007年 / 13卷 / 02期
关键词：
pancreatitis-associated protein; pancreatitis; Janus kinases; STAT3; SOCS3; anti-inflammatory; lectin;
D O I：
10.3748/wjg.v13.i2.170
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Pancreatitis-associated protein (PAP) was discovered in the pancreatic juice of rats with acute pancreatitis. PAP is a 16 kDa secretory protein structurally related to the C-type lectins although classical lectin-related function has not been reported yet. Then, it was demonstrated that PAP expression may be activated in some tissues in a constitutive or injury- and inflammation-induced manner. More recently, it has been found that PAP acts as an anti-inflammatory factor in vitro and in vivo. PAP expression can be induced by several pro- and anti-inflammatory cytokines and by itself through a JAK/STAT3-dependent pathway. PAP is able to activate the expression of the anti-inflammatory factor SOCS3 through the JAK/STAT3-dependent pathway. The JAK/STAT3/SOCS3 pathway seems to be a common point between PAP and several cytokines. Therefore, it is reasonable to propose that PAP is a new anti-inflammatory cytokine. (c) 2007 The WJG Press. All rights reserved.
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页码：170 / 174
页数：5
相关论文
共 43 条
[1]  
Averill S, 2002, J NEUROSCI, V22, P7493
[2]   Pancreatitis-associated protein (HIP/PAP) gene expression is upregulated in NOD mice pancreas and localized in exocrine tissue during diabetes [J].
Baeza, N ;
Sanchez, D ;
Christa, L ;
Guy-Crotte, O ;
Vialettes, B ;
Figarella, C .
DIGESTION, 2001, 64 (04) :233-239
[3]   Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation [J].
Berlato, C ;
Cassatella, MA ;
Kinjyo, I ;
Gatto, L ;
Yoshimura, A ;
Bazzoni, F .
JOURNAL OF IMMUNOLOGY, 2002, 168 (12) :6404-6411
[4]   Pancreatitis-associated protein is upregulated in mouse pancreas during acute pancreatitis [J].
Bödeker, H ;
Fiedler, F ;
Keim, V ;
Dagorn, JC ;
Iovanna, JL .
DIGESTION, 1998, 59 (03) :186-191
[5]   EXPRESSION OF PITUITARY PEPTIDE-23 IN THE RAT UTERUS - REGULATION BY ESTRADIOL [J].
CHAKRABORTY, C ;
VRONTAKIS, M ;
MOLNAR, P ;
SCHROEDTER, IC ;
KATSUMATA, N ;
MURPHY, LJ ;
SHIU, RPC ;
FRIESEN, HG .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1995, 108 (1-2) :149-154
[6]   Presence of pancreatitis-associated protein in pancreatic acinar cells of rats treated with chlorophenylalanine methyl ester [J].
Chen, P ;
Arias, AE ;
Morisset, J ;
Calvo, E ;
Dagorn, JC ;
Iovanna, J ;
Bendayan, M .
PANCREAS, 1996, 13 (02) :147-153
[7]   HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells [J].
Christa, L ;
Carnot, F ;
Simon, MT ;
Levavasseur, F ;
Stinnakre, MG ;
Lasserre, C ;
Thepot, D ;
Clement, B ;
Devinoy, E ;
Brechot, C .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1996, 271 (06) :G993-G1002
[8]   THE HUMAN HIP GENE, OVEREXPRESSED IN PRIMARY LIVER-CANCER ENCODES FOR A C-TYPE CARBOHYDRATE-BINDING PROTEIN WITH LACTOSE BINDING-ACTIVITY [J].
CHRISTA, L ;
FELIN, M ;
MORALI, O ;
SIMON, MT ;
LASSERRE, C ;
BRECHOT, C ;
SEVE, AP .
FEBS LETTERS, 1994, 337 (01) :114-118
[9]   SOCS3 negatively regulates IL-6 signaling in vivo [J].
Croker, BA ;
Krebs, DL ;
Zhang, JG ;
Wormald, S ;
Willson, TA ;
Stanley, EG ;
Robb, L ;
Greenhalgh, CJ ;
Förster, I ;
Clausen, BE ;
Nicola, NA ;
Metcalf, D ;
Hilton, DJ ;
Roberts, AW ;
Alexander, WS .
NATURE IMMUNOLOGY, 2003, 4 (06) :540-545
[10]  
Dieckgraefe BK, 2000, PHYSIOL GENOMICS, V4, P1
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