Association Between the Plasma Levels of Mediators of Inflammation With Pain and Disability in the Elderly With Acute Low Back Pain: Data From the Back Complaints in the Elders (BACE)-Brazil Study

被引：37

作者：

de Queiroz, Barbara Zille ^{[1
]}

Pereira, Daniele Sirineu ^{[2
]}

Lopes, Renata Antunes ^{[1
]}

Felicio, Diogo Carvalho ^{[1
]}

Silva, Juscelio Pereira ^{[1
]}

de Britto Rosa, Nayza Maciel ^{[1
]}

Domingues Dias, Joao Marcos ^{[3
]}

Correa Dias, Rosangela ^{[3
]}

Lustosa, Lygia Paccini ^{[3
]}

Maximo Pereira, Leani Souza ^{[3
]}

机构：

[1] Univ Fed Minas Gerais, Dept Phys Therapy, Postgrad Program Rehabil Sci, Sch Phys Educ Phys Therapy & Occupat Therapy, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Alfenas, Dept Phys Therapy, Alfenas, MG, Brazil

[3] Univ Fed Minas Gerais, Rehabil Sci, Sch Phys Educ Phys Therapy & Occupat Therapy, BR-31270901 Belo Horizonte, MG, Brazil

来源：

SPINE | 2016年 / 41卷 / 03期

关键词：

back complaints in the elders; cytokines; disability; elderly; IL-1; IL-6; inflammation; low back pain; sTNF-R1; TNF-; OLDER-ADULTS; PHYSICAL PERFORMANCE; CYTOKINE LEVELS; ROLAND-MORRIS; TNF-ALPHA; MARKERS; IMPACT; COHORT; WOMEN;

D O I：

10.1097/BRS.0000000000001214

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study Design.Cross-sectional study with subsample of elderly women with acute low back pain (LBP), from Back Complaints in the Elders-Brazil (BACE-Brazil)Objective.To investigate the association between plasma levels of mediators of inflammation (interleukin-1 beta (IL-1), IL-6, tumor necrosis factor alpha (TNF-), and soluble TNF receptor 1 (sTNF-R1)) with pain and disability experienced by elderly women with acute LBP.Summary of Background Data.Among the elderly, LBP is a complaint of great importance and can lead to disability. Inflammatory cytokines are elevated in painful conditions, and may promote pain.Methods.We included 155 community-dwelling elderly women (age 65 yr), who presented with a new (acute) episode of LBP. Enzyme-linked immunosorbent assays were used to measure TNF-, sTNF-R1, IL-1, and IL-6. Disability was assessed using the Roland Morris Disability Questionnaire; pain was assessed using the McGill Pain Questionnaire. Linear regression models were fit with each pain and disability outcome as dependent variables: Present Pain Intensity; Qualities of pain; Severity of pain in the last week; LBP frequency and disability.Results.Depressive symptoms and IL-6 were associated and explained 20.9% of qualities of pain variability. TNF-, sTNFR1, education, body mass index, and depressive symptoms explained 8.4% of Severity of pain in the past week variability. TNF-, education, BMI, depressive symptoms, present pain intensity, qualities of pain, and LBP frequency explained 48.6% of disability. No associations between inflammatory cytokines and present pain intensity and LBP frequency were found.Conclusion.Our results demonstrate associations between inflammatory markers (TNF- and sTNFR1) and pain severity, IL-6 was associated with the qualities of pain, and TNF- was also associated with disability. These inflammatory mediators represent new markers to be considered in the assessment and treatment of elderly patients with LBP.Level of Evidence: 5

引用

页码：197 / 203

页数：7

共 40 条

[1] Chapter 4 - European guidelines for the management of chronic nonspecific low back pain [J].