Biomarkers in anal cancer: from biological understanding to stratified treatment

被引：45
作者：
Jones, Christopher M. [1 ,2 ]
Goh, Vicky [3 ,4 ]
Sebag-Montefiore, David [1 ,2 ]
Gilbert, Duncan C. [5 ]
机构：
[1] Leeds Teaching Hosp NHS Trust, Leeds Canc Ctr, Leeds LS9 7TF, W Yorkshire, England
[2] Univ Leeds, Leeds Inst Canc & Pathol, Leeds LS9 7TF, W Yorkshire, England
[3] Kings Coll London, Div Imaging Sci & Biomed Engn, London SE1 7EH, England
[4] Guys & St Thomas NHS Fdn Trust, Dept Radiol, London SE1 7EH, England
[5] Royal Sussex Cty Hosp, Sussex Canc Ctr, Eastern Rd, Brighton BN2 5BE, E Sussex, England
来源：
BRITISH JOURNAL OF CANCER | 2017年 / 116卷 / 02期
关键词：
anal cancer; chemoradiotherapy; HPV; squamous cell carcinoma of the anus; human papilloma virus; biomarkers; SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS; NECK-CANCER; SURVIVAL; MUTATIONS; CHEMORADIOTHERAPY; P16(INK4A); EXPRESSION; REVEALS; HEAD;
D O I：
10.1038/bjc.2016.398
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Squamous cell carcinomas of the anus and anal canal represent a model of a cancer and perhaps the first where level 1 evidence supported primary chemoradiotherapy (CRT) in treating locoregional disease with curative intent. The majority of tumours are associated with infection with oncogenic subtypes of human papilloma virus and this plays a significant role in their sensitivity to treatment. However, not all tumours are cured with CRT and there remain opportunities to improve outcomes in terms of oncological control and also reducing late toxicities. Understanding the biology of ASCC promises to allow a more personalised approach to treatment, with the development and validation of a range of biomarkers and associated techniques that are the focus of this review.
引用
收藏
页码：156 / 162
页数：7
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