A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor CMI-977

被引：9
作者：
Dixon, DJ
Ley, SV
Reynolds, DJ
Chorghade, MS
机构：
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[2] LeukoSite Inc, Cambridge, MA 02142 USA
来源：
SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 11期
关键词：
D O I：
10.1080/00397910008087245
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A short and efficient synthesis of the potent 5-lipoxygenase inhibitor CMI-977 is described using as the key step a stereoselective anomeric oxygen to carbon rearrangement of an alkynyl stannane tetrahydrofuranyl ether derivative mediated by boron trifluoride etherate.
引用
收藏
页码：1955 / 1961
页数：7
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