MiR-877 suppresses tumor metastasis via regulating FOXM1 in ovarian cancer

Purpose: Ovarian cancer (OC) is a serious threat to women's life. OC is insidious and lacks early diagnosis and effective treatment. Therefore, it is vital to look for new therapeutic targets and biomarkers. Methods: MicroRNA-877 (miR-877) expression level in OC was accessed via quantitative real-time polymerase chain reaction (qRT-PCR). Transwell assay, Matrigel assay and wound healing assay were used to analyze the ability of miR-877 on cell migration and invasion. Luciferase reporter assay was employed for verification the target of miR-877. Western blotting was taken in for the determination of the expression level of FOXM1. Results: MiR-877 had low expression level in OC tissues and cell lines. MiR-877 over-expression induced inhibition of cell migration and invasion. FOXM1 was a direct target of miR-877. MiR-877 restrained cell migration and invasion by negatively regulating FOXM1 expression in OC. Conclusions: Our research elucidated that miR-877 played a role of tumor suppressor in OC by negatively regulating FOXM1 which may bring a novel insight into new molecular therapeutic targets and biomarkers for OC.