Synthesis and biological evaluation of novel resveratrol-oxadiazole hybrid heterocycles as potential antiproliferative agents

被引：26

作者：

Murty, M. S. R. ^{[1
]}

Penthala, Raju ^{[1
]}

Polepalli, Sowjanya ^{[2
]}

Jain, N. ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Discovery Lab, Med Chem & Pharmacol Div, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Ctr Chem Biol, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2016年 / 25卷 / 04期

关键词：

Resveratrol; 1 center dot 3 center dot 4-Oxadiazole 2-thione; Molecular hybridization; Antiproliferative activity; CANCER; DERIVATIVES; APOPTOSIS; ANTICANCER; ANALOG;

D O I：

10.1007/s00044-016-1514-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel class of resveratrol-oxadiazole hybrid compounds was synthesized to screen for their in vitro antiproliferative activity against three human cancer cell lines. All the compounds showed superior antiproliferative activity than the reference compound resveratrol. The most promising active compounds in this series were 1g, 2g, 1c, 2c, 2i and 1a (GI(50) < 0.1 A mu M), endowed with excellent antiproliferative activity. Thus, we believe that resveratrol-oxadiazole hybrid compounds may possibly be used as a good leads for the development of new antiproliferative agents. Structures of newly synthesized compounds were confirmed by NMR and IR spectral data.

引用

页码：627 / 643

页数：17

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