Sarglaperoxides A and B, Sesquiterpene-Normonoterpene Conjugates with a Peroxide Bridge from the Seeds of Sarcandra glabra

被引：56

作者：

Wang, Peng ^{[1
,2
]}

Li, Rui-Jun ^{[1
]}

Liu, Rui-Huan ^{[1
]}

Jian, Kai-Li ^{[1
]}

Yang, Ming-Hua ^{[1
]}

Yang, Lei ^{[1
]}

Kong, Ling-Yi ^{[1
]}

Luo, Jun ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China

[2] Yancheng Teachers Univ, Sch Pharm, Xiwang Rd, Yancheng 224051, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 04期

基金：

中国国家自然科学基金;

关键词：

DIMERIC SESQUITERPENOIDS; CHLORANTHUS; SESTERPENE; SKELETON;

D O I：

10.1021/acs.orglett.6b00112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sarglaperoxides A (1) and B (2), a pair of unusual sesquiterpene-normonoterpene conjugates with a peroxide bridge, were isolated from. the seeds of Sarcandra glabra. The structures and absolute configurations of 1 and 2 were determined on the basis of spectroscopic data analysis, including MS, NMR, CD, and XRD. The two compounds were screened in antimicrobial, anti-inflammatory, and cytotoxic bioassays and showed moderate bioactivities.

引用

页码：832 / 835

页数：4

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