Surgical Neurostimulation for Spinal Cord Injury

被引：41
作者：
Chari, Aswin [1 ,2 ]
Hentall, Ian D. [3 ,4 ]
Papadopoulos, Marios C. [1 ]
Pereira, Erlick A. C. [1 ]
机构：
[1] St Georges Univ London, Acad Neurosurg Unit, London SW17 0RE, England
[2] Imperial Coll London, Div Brain Sci, Fac Med, London W6 8RF, England
[3] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33101 USA
[4] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami, FL 33101 USA
来源：
BRAIN SCIENCES | 2017年 / 7卷 / 02期
关键词：
spinal cord injury; spinal cord stimulation; deep brain stimulation; neuromodulation; DEEP BRAIN-STIMULATION; MOTOR CORTEX STIMULATION; SECONDARY HEALTH CONDITIONS; DORSAL COLUMN STIMULATION; CHRONIC NEUROPATHIC PAIN; ELECTRICAL-STIMULATION; AUTONOMIC DYSFUNCTION; INTRASPINAL PRESSURE; EPIDURAL STIMULATION; NEURONAL-ACTIVITY;
D O I：
10.3390/brainsci7020018
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI. We consider the ability of these therapies to address pain, sensorimotor symptoms and autonomic dysregulation associated with SCI. In addition to the potential to make important contributions to SCI treatment, neuromodulation has the added ability to contribute to our understanding of spinal cord neurobiology and the pathophysiology of SCI.
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页数：17
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