Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones

被引：54

作者：

Hussain, Tanvir ^{[1
]}

Siddiqui, Hamid Latif ^{[1
]}

Zia-ur-Rehman, Muhammad ^{[2
]}

Yasinzai, Muhammad Masoom ^{[3
]}

Parvez, Masood ^{[4
]}

机构：

[1] Univ Punjab, Inst Chem, Lahore 54590, Pakistan

[2] Pakistan Council Sci & Ind Res, Appl Chem Res Ctr, Lahore 54600, Pakistan

[3] Univ Balochistan, Inst Biochem, Quetta, Pakistan

[4] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 11期

关键词：

Imidazole; Chalcones; Anti-oxidant; Anti-fungal; Anti-leishmanial; CHALCONES; INHIBITORS; DESIGN; DERIVATIVES; CRYSTAL;

D O I：

10.1016/j.ejmech.2009.06.038

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones were synthesized by the condensation of various acetophenones with 4-(1H-imidazol-1-yl) benzaldehyde which was itself prepared by the N-arylation of imidazole using hexadecyltrimethylammonium bromide as catalyst for the first time. All the synthesized compounds were subjected to preliminary evaluation for their anti-leishmanial, anti-oxidant and anti-fungal activities. Few of the synthesized compounds showed significant activities. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：4654 / 4660

页数：7

共 30 条

[1]

Ali S. Atif, 1997, Methods in Cell Science, V19, P107, DOI 10.1023/A:1009786915090

[2] SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 2'-HYDROXYCHALCONES AND FLAVONES AS INHIBITORS OF INFLAMMATORY MEDIATORS GENERATION [J].