Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutics and as a Drug Delivery Platform

被引：166

作者：

Baek, Gyuhyeon ^{[1
]}

Choi, Hojun ^{[1
]}

Kim, Youngeun ^{[2
]}

Lee, Hai-Chon ^{[2
]}

Choi, Chulhee ^{[1
,2
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, 291 Daehak Ro, Daejeon 34141, South Korea

[2] ILIAS Biol Inc, 40-20,Techno 6 Ro, Daejeon 34014, South Korea

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2019年 / 8卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

IN-VITRO; MICROVESICLES PROTECT; EXOSOMES; REGENERATION; KIDNEY; INJURY; PHOSPHATIDYLSERINE; BIOGENESIS; INJECTION; VEHICLES;

D O I：

10.1002/sctm.18-0226

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cells (MSCs) are one of the most easily accessible stem cells that can be obtained from various human tissues. They have raised considerable interests for their potential applications in tissue repair, anti-cancer therapy, and inflammation suppression. Stem cell-based therapy was first used to treat muscular dystrophies and has been studied intensively for its efficacy in various disease models, including myocardial infarction, kidney injuries, liver injuries, and cancers. In this review, we summarized the potential mechanisms underlying MSC-derived EVs therapy as a drug delivery platform. Additionally, based on currently published data, we predicted a potential therapeutic role of cargo proteins shuttled by EVs from MSCs. These data may support the therapeutic strategy of using the MSC-derived EVs to accelerate this strategy from bench to bedside. Stem Cells Translational Medicine 2019;8:880&886

引用

页码：880 / 886

页数：7

共 50 条

[21] Mesenchymal Stromal Cell-Derived Extracellular Vesicles as Biological Carriers for Drug Delivery in Cancer Therapy
Sanmartin, Maria Cecilia
Borzone, Francisco Raul
Giorello, Maria Belen
Yannarelli, Gustavo
Chasseing, Norma Alejandra
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 10
[22] Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance
Zhang, Xiaoyan
Tu, Huaijun
Yang, Yazhi
Fang, Lijun
Wu, Qiong
Li, Jian
STEM CELLS INTERNATIONAL, 2017, 2017
[23] Mesenchymal Stem Cell-Derived Extracellular Vesicles: Regenerative Potential and Challenges
Fuloria, Shivkanya
Subramaniyan, Vetriselvan
Dahiya, Rajiv
Dahiya, Sunita
Sudhakar, Kalvatala
Kumari, Usha
Sathasivam, Kathiresan
Meenakshi, Dhanalekshmi Unnikrishnan
Wu, Yuan Seng
Sekar, Mahendran
Malviya, Rishabha
Singh, Amit
Fuloria, Neeraj Kumar
BIOLOGY-BASEL, 2021, 10 (03): : 1 - 31
[24] ! The Therapeutic Potential of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles
Boerger, V.
Goergens, A.
Rohde, E.
Giebel, B.
TRANSFUSIONSMEDIZIN, 2015, 5 (03) : 131 - 137
[25] Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair
Wang, Dongxue
Cao, Hong
Hua, Weizhong
Gao, Lu
Yuan, Yu
Zhou, Xuchang
Zeng, Zhipeng
MEMBRANES, 2022, 12 (07)
[26] Reversal of Aplastic Anemia By Mesenchymal Stem Cell-Derived Extracellular Vesicles
Wen, Sicheng
Dooner, Mark S.
Papa, Elaine
Del Tatto, Michael
Pereira, Mandy
Cheng, Yan
Goldberg, Laura R.
Quesenberry, Peter J.
BLOOD, 2017, 130
[27] Mesenchymal stem cell-derived extracellular vesicles, osteoimmunology and orthopedic diseases
Ma, Maoxiao
Cui, Guofeng
Liu, Youwen
Tang, Yanfeng
Lu, Xiaoshuai
Yue, Chen
Zhang, Xue
PEERJ, 2023, 11
[28] Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
Kyong-Su Park
Elga Bandeira
Ganesh V. Shelke
Cecilia Lässer
Jan Lötvall
Stem Cell Research & Therapy, 10
[29] Mesenchymal Stem Cell-Derived Extracellular Vesicles to the Rescue of Renal Injury
Birtwistle, Lucy
Chen, Xin-Ming
Pollock, Carol
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (12)
[30] Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy
Wang, Ning
Ma, Feifei
Song, Huijuan
He, Ningning
Zhang, Huanteng
Li, Jianguo
Liu, Qiang
Xu, Chang
CELL TRANSPLANTATION, 2025, 34

← 1 2 3 4 5 →