One pot 'click' reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition

被引：80

作者：

Campbell-Verduyn, Lachlan S. ^{[2
]}

Szymanski, Wiktor ^{[2
,3
]}

Postema, Christiaan P. ^{[3
]}

Dierckx, Rudi A. ^{[1
]}

Elsinga, Philip H. ^{[1
]}

Janssen, Dick B. ^{[3
]}

Feringa, Ben L. ^{[2
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands

[2] Univ Groningen, Stratingh Inst Chem, Groningen, Netherlands

[3] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Biochem Lab, Groningen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 06期

关键词：

COPPER-FREE CLICK; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; HALOHYDRIN DEHALOGENASE; TERMINAL ALKYNES; CHEMISTRY; CONVERSION;

D O I：

10.1039/b919434g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Halohydrin dehalogenase (HheC) can perform enantioselective azidolysis of aromatic epoxides to 1,2-azido alcohols which are subsequently ligated to alkynes producing chiral hydroxy triazoles in a one-pot procedure with excellent enantiomeric excess.

引用

页码：898 / 900

页数：3

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