Contribution of FliC to epithelial cell invasion by enterohemorrhagic Escherichia coli O113:H21

被引：24
作者：
Luck, Shelley N.
Badea, Luminita
Bennett-Wood, Vicki
Robins-Browne, Roy
Hartland, Elizabeth L. [1 ]
机构：
[1] Monash Univ, Dept Microbiol, Australian Bacterial Pathogenesis Program, Clayton, Vic 3800, Australia
[2] Univ Melbourne, Dept Microbiol & Immunol, Australian Bacterial Pathogenesis, Melbourne, Vic 3010, Australia
来源：
INFECTION AND IMMUNITY | 2006年 / 74卷 / 12期
关键词：
D O I：
10.1128/IAI.00435-06
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Enterohemorrhagic Escherichia coli (EHEC) O113:1121 can invade epithelial cells. In this study, we found that invasion but not adherence was inhibited by anti-FliC(H21) specific antibodies. In addition, deletion of fliC(H21) from EHEC O113:1121 resulted in an eightfold decrease in invasion that was restored upon transcomplementation with fliC(H21) but not with fliC(H6). These results suggested that FliC plays an important role in the pathogenesis of infections caused by EHEC O113:1121 by allowing bacteria to penetrate the intestinal epithelium.
引用
收藏
页码：6999 / 7004
页数：6
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