Enantioselective reduction of esters:: synthesis of optically active α-acetoxy ethers

被引：9

作者：

Rychnovsky, SD ^{[1
]}

Bax, BM ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)00470-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective reduction and acetylation of esters to alpha-acetoxy ethers is described. Reduction with a NaAlH4-ephedrine reagent followed by in situ acetylation gives 2 with good enantiomeric excess. This reaction is limited in scope, but it demonstrates that enantioselective reductions of esters are possible. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：3593 / 3596

页数：4

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