Pineal hormone melatonin as an adjuvant treatment for COVID-19 (Review)

被引：25

作者：

Vlachou, Marilena ^{[1
]}

Siamidi, Angeliki ^{[1
]}

Dedeloudi, Aikaterini ^{[1
]}

Konstantinidou, Sofia K. ^{[2
,3
]}

Papanastasiou, Ioannis P. ^{[4
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Div Pharmaceut Technol, Dept Pharm, Sch Hlth Sci, Athens 15784, Greece

[2] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Med Sch, Dept Propaedeut Internal Med 1, Athens 11527, Greece

[3] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Med Sch, Diabet Ctr, Athens 11527, Greece

[4] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Div Pharmaceut Chem, Athens 15784, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2021年 / 47卷 / 04期

关键词：

SARS-CoV-2; COVID-19; melatonin; pineal hormone; mechanism of action; clinical trials; OXIDATIVE STRESS; SURVIVAL RATE; ILL PATIENTS; VENEZUELAN; EXPRESSION; APOPTOSIS; BRAIN; PEROXIDATION; INFLAMMATION; MYOCARDITIS;

D O I：

10.3892/ijmm.2021.4880

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The beneficial properties of the pineal hormone, melatonin, as a neuroprotective and cardioprotective agent, have been previously identified. Furthermore, melatonin plays essential roles in biological rhythms resynchronization, sleep initiation/maintenance and metabolic, ocular, rheumatological diseases. In addition to these functions, melatonin is known to exert immunomodulation, anti-inflammatory and anti-oxidative effects. Due to these properties, coupled with its non-toxic nature, melatonin has been suggested to limit viral infections; however, melatonin cannot be classified as a viricidal drug. In addition, the recent increase in the number of clinical trials on melatonin's role, as an adjuvant treatment for COVID-19, has resurged the interest of the scientific community in this hormone. The present short review aimed to improve the understanding of the antiviral/anti-COVID-19 profile of melatonin and the clinical trials that have recently been conducted, with respect to its co-administration in treating individuals with COVID-19.

引用

页数：9

共 85 条

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