Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry

被引：6

作者：

Silva Junior, P. E. ^{[1
]}

Rezende, L. C. D. ^{[1
]}

Gimenes, Julia Possamai ^{[1
]}

Maltarollo, Vinicius Goncalves ^{[2
]}

Dale, James ^{[3
]}

Trossini, G. H. G. ^{[2
]}

Emery, F. S. ^{[1
]}

Ganesan, A. ^{[4
]}

机构：

[1] Univ Sao Paulo, Dept Ciencias Farmaceut, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, Brazil

[2] Univ Sao Paulo, Fac Pharmaceut Sci, Av Lineu Prestes 580,Cid Univ, BR-05508000 Sao Paulo, Brazil

[3] Novartis Horsham Res Ctr, Wimblehurst Rd, Horsham RH12 5AB, W Sussex, England

[4] Univ E Anglia, Sch Pharm, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England

来源：

RSC ADVANCES | 2016年 / 6卷 / 27期

基金：

巴西圣保罗研究基金会;

关键词：

ARYL METHYL ETHERS; DEMETHYLATION;

D O I：

10.1039/c6ra01099g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale.

引用

页码：22777 / 22780

页数：4

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