Selected organophosphorus compounds with biological activity. Applications in medicine

被引：237

作者：

Demkowicz, Sebastian ^{[1
]}

Rachon, Janusz ^{[1
]}

Dasko, Mateusz ^{[1
]}

Kozak, Witold ^{[1
]}

机构：

[1] Gdansk Univ Technol, Fac Chem, Dept Organ Chem, Narutowicza 11-12, PL-80233 Gdansk, Poland

来源：

RSC ADVANCES | 2016年 / 6卷 / 09期

关键词：

STEROID SULFATASE INHIBITORS; MATRIX-METALLOPROTEINASE INHIBITORS; HEPATITIS-C VIRUS; IN-VIVO EVALUATION; ANTICANCER DRUGS; CLINICAL PHARMACOKINETICS; POTENT INHIBITORS; BONE-RESORPTION; PAGETS-DISEASE; GELATINASE-B;

D O I：

10.1039/c5ra25446a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs have become popular in recent years. The practical application of OPs in modern medicine has been attributed to their unique properties. In this article, the methods used to select these compounds will be emphasized. This paper will first outline the findings of a literature review on OPs, including anticancer and antiviral agents, bisphosphonates, phosphorus analogues of amino acids and peptides, and organophosphorus metal complexes, and secondly, it will classify the compounds according to their biological activity and applications in the treatment of diseases.

引用

页码：7101 / 7112

页数：12

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