Review on Experimental Research of Herbal Medicines with Anti-Amnesic Activity

被引：20
作者：
Hsieh, Ming Tsuen [2 ]
Peng, Wen Huang [2 ]
Wu, Chi Rei [2 ]
Ng, Kit Ying [1 ]
Cheng, Chuen Lung [1 ]
Xu, Hong Xi [1 ]
机构：
[1] Hong Kong Jockey Club Inst Chinese Med, Unit 703, Bioinformat Ctr 7F, Shatin, Hong Kong, Peoples R China
[2] China Med Univ, Coll Pharm, Grad Inst Chinese Pharmaceut Sci, Taichung, Taiwan
来源：
PLANTA MEDICA | 2010年 / 76卷 / 03期
关键词：
amnesia; herbal medicines; cholinergic system; GABAergic system; glutaminergic system; memory enhancement; INHIBITORY AVOIDANCE PERFORMANCE; CYCLOHEXIMIDE-INDUCED IMPAIRMENT; SCOPOLAMINE-INDUCED AMNESIA; INDUCED MEMORY IMPAIRMENT; RADIAL MAZE PERFORMANCE; ACORI-GRAMINEI-RHIZOMA; LONG-TERM POTENTIATION; RED GINSENG SAPONINS; ACID-INDUCED AMNESIA; CHOLINE-ACETYLTRANSFERASE;
D O I：
10.1055/s-0029-1240707
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Amnesia is characterized by the inability to form memories or total or partial loss of memory secondary to cerebral malfunction following degenerative diseases, cerebral infections, traumatic injuries and emotional events which could be differentiated from dementia. However, no effective treatment for amnesia is currently available. Much research effort has been focused on developing new drugs from herbal medicines which have multifunctional properties. Novel plant extracts and their major or bioactive components including alkaloids, flavonoids, glycosides and saponins with promising antioxidant effects, various effects on cholinergic, GABAergic, glutaminergic, serotonergic, catecholaminergic and histaminergic systems, enhancement of cerebral blood flow and elevation of ribonucleic acid (RNA) as well as protein levels have been studied. In this review, we discuss the research findings on novel plant extracts and their bioactives with anti-amnesic effects on different neurotransmitter systems. Developing new drugs from herbal medicines for the treatment of amnesia is a hopeful attempt to meet the unmet medical needs.
引用
收藏
页码：203 / 217
页数：15
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