Long-term shedding of viable SARS-CoV-2 in kidney transplant recipients with COVID-19

被引：34

作者：

Benotmane, Ilies ^{[1
,2
,3
]}

Risch, Simone ^{[2
]}

Doderer-Lang, Cecile ^{[4
]}

Caillard, Sophie ^{[1
,3
]}

Fafi-Kremer, Samirad ^{[2
,3
]}

机构：

[1] Strasbourg Univ Hosp, Dept Nephrol & Transplantat, Strasbourg, France

[2] Strasbourg Univ Hosp, Dept Virol, Strasbourg, France

[3] Federat Med Translat FMTS, Strasbourg, France

[4] Strasbourg Univ, Inst Parasitol & Trop Dis Strasbourg, UR7292, Strasbourg, France

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2021年 / 21卷 / 08期

关键词：

clinical research; practice; complication; infectious; infection and infectious agents; viral; infectious disease; kidney transplantation; nephrology; translational research; science;

D O I：

10.1111/ajt.16636

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The exact duration of viable SARS-CoV-2 shedding in kidney transplant recipients (KTRs) remains unclear. Here, we retrospectively investigated this issue using cell cultures of SARS-CoV-2 RT-PCR-positive nasopharyngeal samples (n = 40) obtained from 16 KTRs with symptomatic COVID-19 up to 39 days from symptom onset. A length of viable SARS-CoV-2 shedding >3 weeks from the onset of symptoms was identified in four KTRs (25%). These results suggest that a significant proportion of KTRs can shed viable SARS-CoV-2 for at least 3 weeks, which may favor the emergence of new variants. Based on these data, we recommend prolonging the isolation of KTRs with COVID-19 until negative SARS-CoV-2 RT-PCR testing.

引用

页码：2871 / 2875

页数：5

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