Primary Cilia: Highly Sophisticated Biological Sensors

被引:55
作者
Abou Alaiwi, Wissam A. [1 ]
Lo, Shao T. [1 ]
Nauli, Surya M. [1 ]
机构
[1] MS 607 Univ Toledo, Dept Pharmacol, Toledo, OH 43606 USA
关键词
primary cilia; mechanosensory transduction; calcium; fluid shear stress; POLYCYSTIC KIDNEY-DISEASE; PLANAR CELL POLARITY; BARDET-BIEDL-SYNDROME; AURORA-A; INTRACELLULAR CA2+; OLFACTORY CILIA; GROWTH-FACTOR; PKD1; GENE; PROTEIN; ACTIVATION;
D O I
10.3390/s90907003
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Primary cilia, thin hair-like structures protruding from the apical surface of most mammalian cells, have gained the attention of many researchers over the past decade. Primary cilia are microtubule-filled sensory organelles that are enclosed within the ciliary membrane. They originate at the cell surface from the mother centriole that becomes the mature basal body. In this review, we will discuss recent literatures on the roles of cilia as sophisticated sensory organelles. With particular emphasis on vascular endothelia and renal epithelia, the mechanosensory role of cilia in sensing fluid shear stress will be discussed. Also highlighted is the ciliary involvement in cell cycle regulation, development, cell signaling and cancer. Finally, primary cilia-related disorders will be briefly described.
引用
收藏
页码:7003 / 7020
页数:18
相关论文
共 102 条
[1]   Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades [J].
AbouAlaiwi, Wissam A. ;
Takahashi, Maki ;
Mell, Blair R. ;
Jones, Thomas J. ;
Ratnam, Shobha ;
Kolb, Robert J. ;
Nauli, Surya M. .
CIRCULATION RESEARCH, 2009, 104 (07) :860-869
[2]   Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells [J].
Adato, A ;
Lefèvre, G ;
Delprat, B ;
Michel, V ;
Michalski, N ;
Chardenoux, S ;
Weil, D ;
El-Amraoui, A ;
Petit, C .
HUMAN MOLECULAR GENETICS, 2005, 14 (24) :3921-3932
[3]   Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells [J].
Aguiari, G. ;
Trimi, V. ;
Bogo, M. ;
Mangolini, A. ;
Szabadkai, G. ;
Pinton, P. ;
Witzgall, R. ;
Harris, P. C. ;
Borea, P. A. ;
Rizzuto, R. ;
del Senno, L. .
CELL PROLIFERATION, 2008, 41 (03) :554-573
[4]   Global cytoskeletal control of mechanotransduction in kidney epithelial cells [J].
Alenghat, FJ ;
Nauli, SM ;
Kolb, R ;
Zhou, J ;
Ingber, DE .
EXPERIMENTAL CELL RESEARCH, 2004, 301 (01) :23-30
[5]   Biology of platelet-derived growth factor and its involvement in disease [J].
Alvarez, Ricardo H. ;
Kantarjian, Hagop M. ;
Cortes, Jorge E. .
MAYO CLINIC PROCEEDINGS, 2006, 81 (09) :1241-1257
[6]   Primary cilia: Cellular sensors for the skeleton [J].
Anderson, Charles T. ;
Castillo, Alesha B. ;
Brugmann, Samantha A. ;
Helms, Jill A. ;
Jacobs, Christopher R. ;
Stearns, Tim .
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 2008, 291 (09) :1074-1078
[7]   The centrosome in human genetic disease [J].
Badano, JL ;
Teslovich, TM ;
Katsanis, N .
NATURE REVIEWS GENETICS, 2005, 6 (03) :194-205
[8]   The ciliopathies: An emerging class of human genetic disorders [J].
Badano, Jose L. ;
Mitsuma, Norimasa ;
Beales, Phil L. ;
Katsanis, Nicholas .
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2006, 7 :125-148
[9]   Loss of polycystin-1 causes centrosome amplification and genomic instability [J].
Battini, Lorenzo ;
Macip, Salvador ;
Fedorova, Elena ;
Dikman, Steven ;
Somlo, Stefan ;
Montagna, Cristina ;
Gusella, G. Luca .
HUMAN MOLECULAR GENETICS, 2008, 17 (18) :2819-2833
[10]   Lifting the lid on Pandora's box: the Bardet-Biedl syndrome [J].
Beales, PL .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2005, 15 (03) :315-323