Generation of high drug loading amorphous solid dispersions by Spray Drying

被引：0

作者：

Costa, B. L. A. ^{[1
]}

Sauceau, M. ^{[1
]}

Sescousse, R. ^{[1
]}

Re, M., I ^{[1
]}

机构：

[1] Univ Toulouse, Ecole Mines Albi, UMR CNRS 5302, Ctr RAPSODEE, F-81013 Albi, France

来源：

IDS'2018: 21ST INTERNATIONAL DRYING SYMPOSIUM | 2018年

关键词：

amorphous solid dispersion; spray drying; high drug loading; soluplus; efavirenz;

D O I：

10.4995/ids2018.2018.7871

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Amorphous solid dispersions (ASDs) refers to drug - carrier systems, where the drug is dispersed in the carrier at a molecular level. In this work, ASDs were formulated by spray drying. The aim was to achieve high drug loads of an amorphous hydrophobic drug (Efavirenz - EFV) in the carrier Soluplus (R). Solid state characterizations (mDSC, XRPD, DVS, Raman, SEM, stability and solubility studies) were done. EFV amorphisation in ASDs (20 to 85% EFV loads) resulted in improved drug solubility compared to unprocessed EFV crystals and tendency of properties evolution over time for ASDs with EFV loads higher than 70 wt%.

引用

页码：1123 / 1130

页数：8

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