Antibodies Induced by Dengue Virus Type 1 and 2 Envelope Domain III Recombinant Proteins in Monkeys Neutralize Strains with Different Genotypes

被引：19
作者：
Bernardo, Lidice [1 ]
Fleitas, Osmel [1 ]
Pavon, Alequis [1 ]
Hermida, Lisset [2 ]
Guillen, Gerardo [2 ]
Guzman, Maria G. [1 ]
机构：
[1] Pedro Kouri Trop Med Inst, Dept Virol, PAHO, WHO Collaborating Ctr Study Dengue & Its Vector, Havana, Cuba
[2] Ctr Genet Engn & Biotechnol, Havana 10600, Cuba
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2009年 / 16卷 / 12期
关键词：
MONOCLONAL-ANTIBODIES; AMERICAN GENOTYPES; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; FUSION PROTEIN; GLYCOPROTEIN; EPITOPES; MICE; IMMUNOGENICITY; PATHOGENESIS;
D O I：
10.1128/CVI.00191-09
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the present work, we evaluated the neutralizing capacity of the antibodies induced by dengue virus type 1 and 2 envelope domain III recombinant proteins in monkeys against strains of different dengue virus type 1 and 2 genotypes. Here we demonstrated that dengue virus type 1 and 2 recombinant proteins induced high titers of neutralizing antibodies against different genotype strains.
引用
收藏
页码：1829 / 1831
页数：3
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