Pain relief and quality of life following radiotherapy for bone metastases: a randomised trial of two fractionation schedules

被引：198

作者：

Gaze, MN ^{[1
]}

Kelly, CG ^{[1
]}

Kerr, GR ^{[1
]}

Cull, A ^{[1
]}

Cowie, VJ ^{[1
]}

Gregor, A ^{[1
]}

Howard, GCW ^{[1
]}

Rodger, A ^{[1
]}

机构：

[1] WESTERN GEN HOSP,DEPT CLIN ONCOL,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

来源：

RADIOTHERAPY AND ONCOLOGY | 1997年 / 45卷 / 02期

关键词：

bone metastases; pain relief; palliation; quality of life; radiotherapy fractionation; randomised trial;

D O I：

10.1016/S0167-8140(97)00101-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The optimum dose and fractionation schedule for the palliative irradiation of painful bone metastases is controversial. Purpose: To compare the efficacy, side-effects and effect on quality of life of two commonly used radiotherapy schedules in the management of painful bone metastases. Materials and methods: In a prospective trial, 280 patients were randomised to receive either a single 10 Gy treatment or a course of 22.5 Gy in five daily fractions for the relief of localised metastatic bone pain. Results: Response rates have been calculated from 240 assessable treated sites of pain. The overall response rates were 83.7% (single treatment) and 89.2% (five fractions). The complete response rates were 38.8% (single treatment) and 42.3% (five fractions). The median duration of pain control was 13.5 weeks (single treatment) and 14.0 weeks (five fractions). None of these differences was statistically significant. There were no differences between the groups in the effect of treatment on a variety of quality of life parameters. Conclusions: It is concluded that a single 10 Gy treatment is as effective as a course of 22.5 Gy in five fractions in the management of painful bone metastases. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：109 / 116

页数：8

共 20 条

[1] THE RESPONSIVENESS OF BONE METASTASES TO RADIOTHERAPY - THE EFFECT OF SITE, HISTOLOGY AND RADIATION-DOSE ON PAIN RELIEF [J].

ARCANGELI, G ;

MICHELI, A ;

ARCANGELI, G ;

GIANNARELLI, D ;

LAPASTA, O ;

TOLLIS, A ;

VITULLO, A ;

GHERA, S ;

BENASSI, M .

RADIOTHERAPY AND ONCOLOGY, 1989, 14 (02) :95-101

[2] BONE METASTASIS CONSENSUS STATEMENT [J].

BATES, T ;

YARNOLD, JR ;

BLITZER, P ;

NELSON, OS ;

RUBIN, P ;

MAHER, J .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1992, 23 (01) :215-216

[3]

BLITZER PH, 1985, CANCER, V55, P1486

[4]

Burch HA, 1944, AM J ROENTGENOL RADI, V52, P1

[5]

Cole D J, 1989, Clin Oncol (R Coll Radiol), V1, P59, DOI 10.1016/S0936-6555(89)80035-4

[6]

CRELLIN A, 1989, CLIN ONCOL, V1, P39

[7]

Hoskin P J, 1989, Clin Oncol (R Coll Radiol), V1, P67, DOI 10.1016/S0936-6555(89)80037-8

[8] A PROSPECTIVE RANDOMIZED TRIAL OF 4-GY OR 8-GY SINGLE DOSES IN THE TREATMENT OF METASTATIC BONE PAIN [J].

HOSKIN, PJ ;

PRICE, P ;

EASTON, D ;

REGAN, J ;

AUSTIN, D ;

PALMER, S ;

YARNOLD, JR .

RADIOTHERAPY AND ONCOLOGY, 1992, 23 (02) :74-78

[9] A PROSPECTIVE, RANDOMIZED DOUBLE-BLIND CROSSOVER STUDY TO EXAMINE THE EFFICACY OF SR-89 IN PAIN PALLIATION IN PATIENTS WITH ADVANCED PROSTATE-CANCER METASTATIC TO BONE [J].

LEWINGTON, VJ ;

MCEWAN, AJ ;

ACKERY, DM ;

BAYLY, RJ ;

KEELING, DH ;

MACLEOD, PM ;

PORTER, AT ;

ZIVANOVIC, MA .

EUROPEAN JOURNAL OF CANCER, 1991, 27 (08) :954-958

[10]

MADSEN EL, 1983, INT J RADIAT ONCOL, V9, P1775

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