Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy

被引:109
作者
Boppart, Marni D. [1 ,2 ]
Mahmassani, Ziad S. [3 ]
机构
[1] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL USA
[2] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL USA
[3] Univ Utah, Dept Phys Therapy & Athlet Training, Salt Lake City, UT USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2019年 / 317卷 / 04期
关键词
hypertrophy; ILK; integrin; mTORC; skeletal muscle; FOCAL ADHESION KINASE; SERUM RESPONSE FACTOR; YES-ASSOCIATED PROTEIN; GROWTH-FACTOR RECEPTOR; LINKED KINASE; ALPHA-7-BETA-1; INTEGRIN; HIPPO PATHWAY; MYOTENDINOUS JUNCTION; EXTRACELLULAR-MATRIX; MAMMALIAN TARGET;
D O I
10.1152/ajpcell.00009.2019
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The alpha(7)beta(1)-integrin is a transmembrane adhesion protein that connects laminin in the extracellular matrix (ECM) with actin in skeletal muscle fibers. The alpha(7)beta(1)-integrin is highly expressed in skeletal muscle and is concentrated at costameres and myotendious junctions, providing the opportunity to transmit longitudinal and lateral forces across the membrane. Studies have demonstrated that alpha(7) -integrin subunit mRNA and protein are upregulated following eccentric contractions as a mechanism to reinforce load-bearing structures and resist injury with repeated bouts of exercise. It has been hypothesized for many years that the integrin can also promote protein turnover in a manner that can promote beneficial adaptations with resistance exercise training, including hypertrophy. This review provides basic information about integrin structure and activation and then explores its potential to serve as a critical mechanosensor and activator of muscle protein synthesis and growth. Overall, the hypothesis is proposed that the alpha(7)beta(1)-integrin can contribute to mechanical-load induced skeletal muscle growth via an mammalian target of rapamycin complex 1-independent mechanism.
引用
收藏
页码:C629 / C641
页数:13
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