Therapeutic monitoring of calcineurin inhibitors for the nephrologist

被引：216

作者：

Schiff, Jeffrey

Cole, Edward

Cantarovich, Marcelo

机构：

[1] McGill Univ, Royal Victoria Hosp, Ctr Hlth, Multiorgan Transplant Program, Montreal, PQ H3A 1A1, Canada

[2] Toronto Gen Hosp, Univ Hlth Network, Div Nephrol, Toronto, ON, Canada

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2007年 / 2卷 / 02期

关键词：

D O I：

10.2215/CJN.03791106

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The calcineurin inhibitors (CNI) cyclosporine and tacrolimus remain the backbone of immunosuppression for most kidney transplant recipients. Despite many years of experience, protocols that optimize efficacy with minimal toxicity remain a subject of debate. Nevertheless, studies of the pharmacokinetic properties of the CNI, particularly cyclosporine, have led to improved dosing strategies. The purpose of this article is to review the current understanding of CNI pharmacokinetics and its relevance to proper dosing and monitoring of these medications. This article also reviews the trials that have helped to define the optimal dosages and discusses the effect of adjunctive immunosuppressive agents on CNI pharmacokinetics and dosing.

引用

页码：374 / 384

页数：11

共 108 条

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