Novel fluorescent probe with a bridged Si-O-Si bond for the reversible detection of hypochlorous acid and biothiol amino acids in live cells and zebrafish

被引：19
作者：
Zhang, Yu [1 ]
Zuo, Yujing [1 ]
Yang, Tingxin [1 ]
Gou, Zhiming [1 ]
Wang, Xiaoni [1 ]
Lin, Weiying [1 ]
机构：
[1] Univ Jinan, Sch Mat Sci & Engn, Inst Fluorescent Probes Biol Imaging, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China
来源：
ANALYST | 2019年 / 144卷 / 17期
关键词：
RATIOMETRIC DETECTION; OXIDATIVE STRESS; LIVING CELLS; IMAGING HOCL; FORMALDEHYDE; DESIGN; TISSUE; QUANTIFICATION; MITOCHONDRIA; LYSOSOME;
D O I：
10.1039/c9an00844f
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Herein, we report the design of a novel fluorescent probe consisting of a naphthalimide fluorophore and a silicone small molecule for the reversible detection of hypochlorous acid and biothiol amino acids. The response mechanism of BSi-1 is based on the concept of the S-based oxidation/reduction. The probe was found to be suitable for imaging HOCl in HeLa, RAW 264.7 cells and zebrafish, demonstrating its utility in biological applications.
引用
收藏
页码：5075 / 5080
页数：6
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