Stem cells therapy in acute myocardial infarction: a new era?

被引：19
作者：
Carbone, R. G. [1 ]
Monselise, A. [2 ]
Bottino, G. [1 ]
Negrini, S. [1 ]
Puppo, F. [1 ]
机构：
[1] Univ Genoa, Dept Internal Med, Genoa, Italy
[2] Tel Aviv Univ, Tel Aviv, Israel
来源：
CLINICAL AND EXPERIMENTAL MEDICINE | 2021年 / 21卷 / 02期
关键词：
Stem cells; Bone marrow cells; Acute myocardial infarction; Transplantation; Clinical trials; BONE-MARROW-CELLS; COLONY-STIMULATING FACTOR; LEFT-VENTRICULAR FUNCTION; CORONARY-ARTERY-DISEASE; INTRACORONARY INFUSION; MONONUCLEAR-CELLS; DOUBLE-BLIND; PROGENITOR CELLS; REGENERATION ENHANCEMENT; ISCHEMIC-HEART;
D O I：
10.1007/s10238-021-00682-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Stem cells transplantation after acute myocardial infarction (AMI) has been claimed to restore cardiac function. However, this therapy is still restricted to experimental studies and clinical trials. Early un-blinded studies suggested a benefit from stem cell therapy following AMI. More recent blinded randomized trials have produced mixed results and, notably, the last largest pan-European clinical trial showed the inconclusive results. Furthermore, mechanisms of potential benefit remain uncertain. This review analytically evaluates 34 blinded and un-blinded clinical trials comprising 3142 patients and is aimed to: (1) identify the pros and cons of stem cell therapy up to a 6-month follow-up after AMI comparing benefit or no effectiveness reported in clinical trials; (2) provide useful information for planning future clinical programs of cardiac stem cell therapy.
引用
收藏
页码：231 / 237
页数：7
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