DNA - Gold Nanoparticles Designed for mRNA Sensing in Cells: Imaging of the Gold Nanoparticles Using Two Photon Photoluminescence Spectroscopy

被引：0
作者：
Kyriazi, Maria-Eleni [1 ]
Muskens, Otto L. [1 ,2 ]
Kanaras, Antonios G. [1 ,2 ]
机构：
[1] Univ Southampton, Sch Phys & Astron, Southampton SO17 1BJ, Hants, England
[2] Univ Southampton, Inst Life Sci, Southampton SO17 1BJ, Hants, England
来源：
COLLOIDAL NANOPARTICLES FOR BIOMEDICAL APPLICATIONS XIV | 2019年 / 10892卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
DNA; mRNA; nanoparticles; colloids; drugs; cancer; TPPL; SIZE; NANORODS; ABSORPTION; PLATFORM; PROBE;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Recently DNA - coated gold nanoparticles have emerged as ideal tools for the detection of mRNA in cells using dye modified oligonucleotides. However, the tracking of the gold core has been hindered by the small size of the particle core. In this work we utilize a home built set up and 43 nm DNA - coated spherical gold nanoparticles for the simultaneous imaging of mRNA detection using fluorescence microscopy and the gold nanoparticle core using two photon photoluminescence (TPPL).
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页数：10
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