New insights into the molecular complexity of the ghrelin gene locus

被引：37
作者：
Seim, Inge
Herington, Adrian C.
Chopin, Lisa K. [1 ]
机构：
[1] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4000, Australia
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 04期
关键词：
Ghrelin; Peptides; Crypteins; Alternative splicing; ncRNA; GROWTH-HORMONE SECRETAGOGUE; PLASMA OBESTATIN LEVELS; CARCINOMA-CELL-LINE; GHRELIN/MOTILIN-RELATED PEPTIDE; PRADER-WILLI-SYNDROME; LONG NONCODING RNAS; DES-ACYL GHRELIN; GENOMIC STRUCTURE; FOOD-INTAKE; IN-VITRO;
D O I：
10.1016/j.cytogfr.2009.07.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ghrelin is a multi-functional peptide hormone that affects a range of processes, including growth hormone and insulin release, appetite regulation, reproduction, and cancer cell proliferation. The main focus of this review is to advance the hypothesis that the ghrelin gene locus encodes an array of biologically active molecules in addition to ghrelin and is far more complex than currently appreciated. Alternative splicing and the use of alternative post-translational cleavages sites may give rise to novel ghrelin gene-derived peptides that potentially act through different receptors and have novel biological functions. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：297 / 304
页数：8
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