New insights into the molecular complexity of the ghrelin gene locus

被引：37

作者：

Seim, Inge

Herington, Adrian C.

Chopin, Lisa K. ^{[1
]}

机构：

[1] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4000, Australia

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 04期

关键词：

Ghrelin; Peptides; Crypteins; Alternative splicing; ncRNA; GROWTH-HORMONE SECRETAGOGUE; PLASMA OBESTATIN LEVELS; CARCINOMA-CELL-LINE; GHRELIN/MOTILIN-RELATED PEPTIDE; PRADER-WILLI-SYNDROME; LONG NONCODING RNAS; DES-ACYL GHRELIN; GENOMIC STRUCTURE; FOOD-INTAKE; IN-VITRO;

D O I：

10.1016/j.cytogfr.2009.07.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin is a multi-functional peptide hormone that affects a range of processes, including growth hormone and insulin release, appetite regulation, reproduction, and cancer cell proliferation. The main focus of this review is to advance the hypothesis that the ghrelin gene locus encodes an array of biologically active molecules in addition to ghrelin and is far more complex than currently appreciated. Alternative splicing and the use of alternative post-translational cleavages sites may give rise to novel ghrelin gene-derived peptides that potentially act through different receptors and have novel biological functions. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：297 / 304

页数：8

共 142 条

[1] Plasma obestatin is lower at fasting and not suppressed by insulin in insulin-resistant humans [J].

Anderwald-Stadler, Marietta ;

Krebs, Michael ;

Promintzer, Miriam ;

Mandl, Martina ;

Bischof, Martin G. ;

Nowotny, Peter ;

Kaestenbauer, Thomas ;

Luger, Anton ;

Prager, Rudolf ;

Anderwald, Christian .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (05) :E1393-E1398

[2] Antagonism of ghrelin receptor reduces food intake and body weight gain in mice [J].

Asakawa, A ;

Inui, A ;

Kaga, T ;

Katsuura, G ;

Fujimiya, M ;

Fujino, MA ;

Kasuga, M .

GUT, 2003, 52 (07) :947-952

[3] The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities [J].

Autelitano, DJ ;

Rajic, A ;

Smith, AI ;

Berndt, MC ;

Ilag, LL ;

Vadas, M .

DRUG DISCOVERY TODAY, 2006, 11 (7-8) :306-314

[4] Characterisation of proghrelin peptides in mammalian tissue and plasma [J].

Bang, Angela S. ;

Soule, Steven G. ;

Yandle, Tim G. ;

Richards, A. Mark ;

Pemberton, Chris J. .

JOURNAL OF ENDOCRINOLOGY, 2007, 192 (02) :313-323

[5] Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract [J].

Bassil, A. K. ;

Haglund, Y. ;

Brown, J. ;

Rudholm, T. ;

Hellstrom, P. M. ;

Naslund, E. ;

Lee, K. ;

Sanger, G. J. .

BRITISH JOURNAL OF PHARMACOLOGY, 2007, 150 (01) :58-64

[6] Characteristics Associated With Fasting Appetite Hormones (Obestatin, Ghrelin, and Leptin) [J].

Beasley, Jeannette M. ;

Ange, Brett A. ;

Anderson, Cheryl A. M. ;

Miller, Edgar R., III ;

Holbrook, Janet T. ;

Appel, Lawrence J. .

OBESITY, 2009, 17 (02) :349-354

[7] Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a [J].

Bednarek, MA ;

Feighner, SD ;

Pong, SS ;

McKee, KK ;

Hreniuk, DL ;

Silva, MV ;

Warren, VA ;

Howard, AD ;

Van der Ploeg, LHY ;

Heck, JV .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (23) :4370-4376

[8] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project [J].

Birney, Ewan ;

Stamatoyannopoulos, John A. ;

Dutta, Anindya ;

Guigo, Roderic ;

Gingeras, Thomas R. ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Snyder, Michael ;

Dermitzakis, Emmanouil T. ;

Stamatoyannopoulos, John A. ;

Thurman, Robert E. ;

Kuehn, Michael S. ;

Taylor, Christopher M. ;

Neph, Shane ;

Koch, Christoph M. ;

Asthana, Saurabh ;

Malhotra, Ankit ;

Adzhubei, Ivan ;

Greenbaum, Jason A. ;

Andrews, Robert M. ;

Flicek, Paul ;

Boyle, Patrick J. ;

Cao, Hua ;

Carter, Nigel P. ;

Clelland, Gayle K. ;

Davis, Sean ;

Day, Nathan ;

Dhami, Pawandeep ;

Dillon, Shane C. ;

Dorschner, Michael O. ;

Fiegler, Heike ;

Giresi, Paul G. ;

Goldy, Jeff ;

Hawrylycz, Michael ;

Haydock, Andrew ;

Humbert, Richard ;

James, Keith D. ;

Johnson, Brett E. ;

Johnson, Ericka M. ;

Frum, Tristan T. ;

Rosenzweig, Elizabeth R. ;

Karnani, Neerja ;

Lee, Kirsten ;

Lefebvre, Gregory C. ;

Navas, Patrick A. ;

Neri, Fidencio ;

Parker, Stephen C. J. ;

Sabo, Peter J. ;

Sandstrom, Richard ;

Shafer, Anthony .

NATURE, 2007, 447 (7146) :799-816

[9] Plasma obestatin and ghrelin levels in subjects with Prader-Willi syndrome [J].

Butler, Merlin G. ;

Bittel, Douglas C. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2007, 143A (05) :415-421

[10] Obestatin-mediated proliferation of human retinal pigment epithelial cells:: Regulatory mechanisms [J].

Camina, Jesus P. ;

Campos, Jacobo F. ;

Caminos, J. Eduardo ;

Dieguez, Carlos ;

Casanueva, Felipe F. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 211 (01) :1-9

← 1 2 3 4 5 6 7 8 9 10 →