Brucella-induced thrombocytopenia: a retrospective study of 16 patients

Objective We aimed to describe the clinical characteristics and treatment outcomes of 16 patients with Brucella-induced thrombocytopenia. Methods We assessed 16 patients with Brucella-induced thrombocytopenia between 2012 and 2016 in The First Affiliated Hospital of Xinjiang Medical University. The diagnosis of Brucella-induced thrombocytopenia was <= 100,000 platelets/mm(3). Results All patients were men. The most common symptoms of patients were fever (100%), sweating (81.2%), fatigue (75%), and joint pain (25%). The most common signs of physical examinations were an enlarged liver (75%) and enlarged spleen (50%). The lowest thrombocyte count was 2000/mm(3) and the highest count was 72,000/mm(3). An agglutination test antibody was positive (>= 1:160) in 12 (75%) patients with the highest antibody titer of 1:800. Brucella melitensis was isolated from blood cultures in nine (56.3%) patients. All patients were administered antimicrobial agents. The patients' platelet counts were normal at a follow-up of 12 months. Conclusion Classical brucellosis therapy is adequate for patients with a platelet count > 20,000/mm(3). The five-drug regimen of doxycycline + rifampin + platelet transfusions + corticosteroids + intravenous immunoglobulin is recommended for patients when the platelet count is < 10,000/mm(3). These findings have important implications for improving treatment outcome in patients with Brucella-induced thrombocytopenia.