Cutaneous biocompatible rutin-loaded gelatin-based nanoparticles increase the SPF of the association of UVA and UVB filters

被引：78

作者：

de Oliveira, Camila Areias ^{[1
]}

Peres, Daniela D'Almeida ^{[1
]}

Graziola, Fabiana ^{[1
]}

Bou Chacra, Nadia Araci ^{[1
]}

Barros de Araujo, Gabriel Lima ^{[1
]}

Florido, Ana Catarina ^{[2
]}

Mota, Joana ^{[2
]}

Rosado, Catarina ^{[2
]}

Robles Velasco, Maria Valeria ^{[1
]}

Rodrigues, Luis Monteiro ^{[2
]}

Fernandes, Ana Sofia ^{[2
]}

Baby, Andre Rolim ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharm, Lab Cosmetol, BR-05508900 Sao Paulo, SP, Brazil

[2] Univ Lusofona, Res Ctr Biosci & Hlth Technol, CBIOS, Lisbon, Portugal

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2016年 / 81卷

基金：

巴西圣保罗研究基金会;

关键词：

Gelatin; Rutin; Nanoparticle; Sunscreen; ANTIOXIDANT ACTIVITY; TRACKING ANALYSIS; SKIN; QUERCETIN; DRUG; PHOTOSTABILIZATION; PHOTOPROTECTION; DEGRADATION; MICROSCOPY; SUNSCREEN;

D O I：

10.1016/j.ejps.2015.09.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The encapsulation of natural ingredients, such as rutin, can offer improvements in sun protection effectiveness. This strategy can provide enhanced flavonoid content and produces an improved bioactive compound with new physical and functional characteristics. As an alternative to common synthetic-based sunscreens, rutin-entrapped gelatin nanoparticles (GNPs) were designed and associated with ethylhexyl dimethyl PABA (EHDP), ethylhexyl methoxycinnamate (EHMC) and methoxydibenzoylmethane (BMDBM) in sunscreen formulations. The purpose of this study was to develop rutin-loaded gelatin nanoparticles and characterize their physicochemical, thermal, functional and safety properties. Rutin-loaded gelatin nanoparticles increased antioxidant activity by 74% relative to free-rutin (FR) solution. Also, this new ingredient upgraded the Sun Protection Factor (SPF) by 48%, indicating its potential as a raw material for bioactive sunscreens. The safety profile indicated that GNPs and glutaraldehyde (GTA) decreased HaCaT cell viability in a concentration/time-dependent manner. However, both blank nanoparticles (B-NC) and rutin-loaded nanoparticles (R-NC) had good performance on skin compatibility tests. These results functionally characterized rutin-loaded nanoparticles as a safe SPF enhancer in sunscreens, especially in association with UV filters. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：1 / 9

页数：9

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