The Prognostic Value of Soluble Intercellular Adhesion Molecule 1 Plasma Level in Children With Acute Lung Injury

被引:10
作者
Al-Biltagi, Mohammed A. [1 ]
Abo-Elezz, Ahmed Ahmed Abd ElBasset [1 ]
Abu-Ela, Khaled Talaat [1 ]
Suliman, Ghada Abudelmomen [2 ]
Sultan, Tamer Gomaa Hassan [1 ]
机构
[1] Tanta Univ, Dept Pediat, Fac Med, Med Complex,Qism 2, Tanta 11432, Egypt
[2] Tanta Univ, Dept Clin Pathol, Fac Med, Tanta, Egypt
关键词
acute lung injury; acute respiratory distress syndrome; C-reactive protein; soluble intercellular adhesion molecule 1; sICAM-1; prognosis; children; RESPIRATORY-DISTRESS-SYNDROME; ARDS; SICAM-1;
D O I
10.1177/0885066615605071
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objective: The objective of this study was to evaluate the prognostic significance of soluble intercellular adhesion molecule 1 (sICAM-1) measurement in plasma for the prediction of outcome of acute lung injury (ALI) in children that may allow early recognition of critical cases. Methods: The study was performed as a prospective, controlled cohort study involving 40 children with ALI and 30 healthy children. The plasma level of sICAM-1 was measured at days 1 and 3 of development of ALI for the patient group and measured only once for the control group. C-Reactive protein was measured in both groups on day 1 only. Results: There was significant increase in sICAM-1 in the patient group than in the control group (P = .001*). The mortality rate reached 55% in children with ALI. The ceased group had significantly higher plasma sICAM-1 levels both at days 1 and 3 than the survived group (P < .001*), and there was positive correlation between plasma sICAM-1 level and both duration of mechanical ventilation and the death rate, but more significant correlation was observed with plasma sICAM-1 levels at day 3 than day 1. Conclusion: Plasma sICAM-1 level served as a good predictor biomarker for both mechanical ventilation duration and the mortality risk in children with ALI.
引用
收藏
页码:320 / 325
页数:6
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