De Novo and Recurrence of Nonalcoholic Steatohepatitis After Liver Transplantation

被引：21

作者：

Kappus, Matthew ^{[1
]}

Abdelmalek, Manal ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Div Gastroenterol, 40 Duke Med Circle,POB 3913, Durham, NC 27710 USA

来源：

CLINICS IN LIVER DISEASE | 2017年 / 21卷 / 02期

关键词：

Nonalcoholic fatty liver disease; Insulin resistance; Hyperlipidemia; Hypertension; Obesity; Metabolic syndrome; Cryptogenic cirrhosis; LYSOSOMAL ACID LIPASE; LONG-TERM OUTCOMES; FATTY LIVER; METABOLIC SYNDROME; HEPATIC STEATOSIS; UNITED-STATES; RISK-FACTORS; WEIGHT-GAIN; RENAL-TRANSPLANTATION; CYCLOSPORINE-A;

D O I：

10.1016/j.cld.2016.12.006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developing countries. Approximately 25% of patients with NAFLD develop nonalcoholic steatohepatitis (NASH). NASH-related cirrhosis is now a leading listing indication for liver transplantation in the United States. Although posttransplant survival for NASH-related cirrhosis is comparable with that of other liver diseases, many patients have features of metabolic syndrome, which can contribute to a recurrence of NAFLD or NASH. This article reviews the epidemiology, pathophysiology, and treatment of de novo and recurrence of NASH after liver transplantation.

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页码：321 / +

页数：17

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