Synthesis and biological activity of new sugar modified 2',5'-oligoadenylate trimers

被引：0
|
作者：
Kvasyuk, EI
Kulak, TI
Tkachenko, OV
Sentyureva, SL
Mikhailopulo, IA
Suhadolnik, RJ
Henderson, EE
Horvath, SE
Guan, MX
Pfleiderer, W
机构：
[1] TEMPLE UNIV, SCH MED, FELS INST CANC RES & MOL BIOL, DEPT MICROBIOL & IMMUNOL, PHILADELPHIA, PA 19140 USA
[2] UNIV KONSTANZ, FAK CHEM, D-78434 CONSTANCE, GERMANY
[3] TEMPLE UNIV, SCH MED, FELS INST CANC RES & MOL BIOL, DEPT BIOCHEM, PHILADELPHIA, PA 19140 USA
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1997年 / 16卷 / 5-6期
关键词：
D O I：
10.1080/07328319708002949
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New 2',5'-oligonucleotide trimers containing 2',3'-dideoxy-3'-fluoro derivatives of adenosine at the 2'-terminal end of oligomers have been synthesized. Some of the synthesized trimers showed biological inhibitions of HIV-1 reverse transcriptase and HIV-1 induced syncytia formation.
引用
收藏
页码：773 / 776
页数：4
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