Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1

被引：24
作者：
Fu, Yuan-Gen
Sung, Joseph J. Y.
Wu, Kai-Chun
Bai, Alfa H. C.
Chan, Martin C. W.
Yu, Jun
Fan, Dai-Ming
Leung, Wai K.
机构：
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Inst Digest Dis, Xian, Peoples R China
来源：
CANCER LETTERS | 2006年 / 243卷 / 02期
关键词：
angiogenesis; angiopoietin; gastric cancer; peroxisome proliferators activated receptor;
D O I：
10.1016/j.canlet.2005.11.039
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Peroxisome proliferator-activated receptor gamma (PPAR gamma) ligands have been shown to inhibit angiogenesis. We showed that treatment with 15d-PGJ(2), a PPAR gamma ligand, downregulate the expressions of angiopoictin-1 (Ang-1) in gastric cancer cells MKN45. The medium of MKN45 cells treated with 15d-PGJ2 significantly inhibited the migration and tube formation of human umbilical vein endothelial cells (HUVECs). Moreover, Matrigel plug assay revealed that 15d-PGJ2 reduced in vivo angiogenesis induced by MKN45 cells. These modulations were restored by the addition of recombinant Ang-1. Our findings supported that 15d-PGJ2 suppressed angiogenesis of gastric cancer cells by downregulation of Ang-1. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：246 / 254
页数：9
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