Asthma exacerbations: the Achilles heel of asthma care

被引：13

作者：

McIntyre, Amanda ^{[1
]}

Busse, William W. ^{[1
]}

机构：

[1] Univ Wisconsin Sch Med & Publ Hlth, Dept Med, Div Allergy, Pulm & Crit Care Med, Madison, WI USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2022年 / 28卷 / 12期

关键词：

CORONAVIRUS DISEASE 2019; RESPIRATORY ILLNESS; VIRAL-INFECTIONS; CHILDHOOD ASTHMA; TOTAL IGE; CHILDREN; VIRUS; SEVERITY; RISK; POLYMORPHISMS;

D O I：

10.1016/j.molmed.2022.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Asthma exacerbations significantly impact millions of patients worldwide to pose large disease burdens on affected patients, families, and health-care sys-tems. Although numerous environmental factors cause asthma exacerbations, viral respiratory infections are the principal triggers. Advances in the pathophys-iology of asthma have elucidated dysregulated protective immune responses and upregulated inflammation that create susceptibility and risks for exacerba-tion. Biologics for the treatment of severe asthma reduce rates of exacerbations and identify specific pathways of inflammation that contribute to altered patho-physiology, novel therapeutic targets, and informative biomarkers. Major steps to prevent exacerbations include the identification of molecular pathways whose blockage will prevent asthma attacks safely, predictably, and effectively.

引用

页码：1112 / 1127

页数：16

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