Synthesis and characterization of N-succinyl-chitosan and its self-assembly of nanospheres

被引：124
|
作者：
Zhu Aiping [1 ]
Chen Tian [1 ]
Yuan Lanhua [1 ]
Wu Hao [1 ]
Lu Ping [1 ]
机构：
[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2006年 / 66卷 / 02期
关键词：
chitosan; N-succinyl-chitosan; self-assembly; nanosphere;
D O I：
10.1016/j.carbpol.2006.03.014
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A simple and novel method was developed to synthesize successfully the N-succinyl-chitosan (NSCS). The NSCS was characterized by FTIR, H-1 NMR, element analysis and XRD. NSCS can be self-assembly of well-dispersed and stable nanospheres in distilled water. The morphology of the nanosphere was investigated by transmission electron microscope (TEM) and shows 50-100 nm in diameter. The steady-state fluorescence spectroscopy indicates that the hydrophobic domain has been formed within these NSCS nanospheres. The assembly mechanisms are believed to be the intermolecular H-bonding of NSCS and hydrophobic interaction among the hydrophobic moieties in NSCS macromolecules. The in vitro cell culture indicates that NSCS has non-toxicity and cell-compatibility. Our results demonstrate that NSCS has great potential in the drug controlled release delivery. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：274 / 279
页数：6
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