Caveolin-1 and liver regeneration - Role in proliferation and lipogenesis

被引：20
|
作者：
Frank, Philippe G. [1 ]
Lisanti, Michael P. [1 ]
机构：
[1] Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
来源：
CELL CYCLE | 2007年 / 6卷 / 02期
关键词：
caveolin; liver regeneration; lipogenesis; triglycerides; fatty acids;
D O I：
10.4161/cc.6.2.3722
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Caveolin-1 is an essential component of caveolae, which form 50-100 nm cell surface plasma membrane invaginations. Caveolin-1 has been previously implicated in the regulation of cellular proliferation and lipogenesis. Current data now suggest that caveolin-1 plays an essential role in the regulation of liver regeneration and that it is implicated in the regulation of triglyceride accumulation, which is an essential process that plays a critical role in the regulation of liver regeneration. These findings are consistent with the importance of a lipogenesis program in the regulation of liver regeneration.
引用
收藏
页码：115 / 116
页数：2
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