Mechanism for improving stereoselectivity for asymmetric reduction using acetone powder of microorganism

被引：25

作者：

Matsuda, T

Harada, T

Nakajima, N

Nakamura, K ^{[3
]}

机构：

[1] Ryukoku Univ, Fac Sci & Technol, Dept Mat Chem, Otsu, Shiga 5202194, Japan

[2] Okayama Prefectural Univ, Fac Hlth & Welfare, Dept Nutr Sci, Okayama 7191112, Japan

[3] Kyoto Univ, Chem Res Inst, Uji, Kyoto 6110011, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 21期

关键词：

enantiocontrol; enzymes and enzyme reactions; coenzymes; reduction;

D O I：

10.1016/S0040-4039(00)00552-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The mechanism of a dramatic improvement in stereoselectivity for the reduction of ketones using acetone powder of Geotrichum candidum is elucidated by examining stereoselectivity of the cell-free system. The improvement in stereoselectivity by the present method was also applicable to the reactions with enzymes from other kinds of microorganisms, (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4135 / 4138

页数：4