Focal lesions of the corticospinal tract demonstrated by diffusion tensor imaging in patients with diffuse axonal injury

被引:6
作者
Ahn, Young Hwan
Kim, Seong Ho
Han, Bong Soo
Kim, Oh Lyong
Ahn, Sang Ho
Cho, Yoon Woo
Kwon, Yong-Hyun
Jang, Sung Ho
机构
[1] Yeungnam Univ, Sch Med, Dept Phys Med & Rehabil, Taegu 705717, South Korea
[2] Ajou Univ, Sch Med, Dept Neurosurg, Suwon 441749, South Korea
[3] Yeungnam Univ, Sch Med, Dept Neurosurg, Taegu 705717, South Korea
[4] Yonsei Univ, Coll Hlth Sci, Dept Radiol Sci, Kangwon Do, South Korea
关键词
motor recovery; diffusion tensor imaging; corticospinal tract; diffuse axonal injury;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives: Diffusion tensor imaging (DTI) with fiber tractography (FT) could be useful for exploration of the state of the corticospinal tract (CST) at the subcortical white matter level. The purpose of this study was to demonstrate focal lesions of the CST in patients with diffuse axonal injury (DAI), using DTI with FT. Design: Two patients with DAI and six normal control subjects were recruited to this study. DTI was performed using 1.5-T with a synergy-L Sensitivity Encoding ( SENSE) head coil. Fractional anisotropy ( FA) and apparent diffusion coefficients (ADC) were measured using a region of interest (ROI) method. FTs were obtained with FA < 0.3 and an angle change > 45. as termination criteria. Results: On the DTI with FT, the focal lesions, which could not observed using routine brain MRI, were detected in the left brainstem of patient 1 and in the right pons and the left and right medulla of patient 2. The patients showed significantly decreased FA values in the focal lesions compared to normal controls. Conclusions: DTI with FT demonstrated focal lesions at the brainstem that had not been revealed by conventional brain MRI; these focal lesions explained the weaknesses of the patients. We conclude that DTI with FT may be a useful modality for use in investigating the status of CST in patients with DAI.
引用
收藏
页码:239 / 243
页数:5
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