Lipids on the move: phosphoinositide 3-kinases in leukocyte function

被引:109
|
作者
Wymann, MP [1 ]
Sozzani, S
Altruda, F
Mantovani, A
Hirsch, E
机构
[1] Univ Fribourg, Inst Biochem, CH-1700 Fribourg, Switzerland
[2] Ist Ric Farmacol Mario Negri, Milan, Italy
[3] Univ Turin, Dept Genet Biol & Biochem, I-10126 Turin, Italy
[4] Univ Brescia, Sect Gen Pathol, Brescia, Italy
来源
IMMUNOLOGY TODAY | 2000年 / 21卷 / 06期
关键词
D O I
10.1016/S0167-5699(00)01649-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
All four known cell surface receptor-activated phosphoinositide 3-kinases have been found in leukocytes. Matthias Wymann and colleagues discuss their nonredundant roles in leukocyte function, particularly in chemotaxis, and their promise as targets for therapeutic intervention.
引用
收藏
页码:260 / 264
页数:5
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