Induction of tolerance and mossy fibre neuropeptide-Y expression in the contralateral hippocampus following a unilateral intrahippocampal kainic acid injection in the rat

被引：16
作者：
ElBahh, B
Lurton, D
Sundstrom, LE
Rougier, A
机构：
[1] UNIV BORDEAUX 2,LAB NEUROBIOL & NEUROIMAGERIE EXPT,F-33076 BORDEAUX,FRANCE
[2] SOUTHAMPTON GEN HOSP,SOUTHAMPTON SO9 4XY,HANTS,ENGLAND
来源：
NEUROSCIENCE LETTERS | 1997年 / 227卷 / 02期
关键词：
kainic acid; epilepsy; neuropeptide-Y; hippocampus; neuroprotection;
D O I：
10.1016/S0304-3940(97)00261-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have previously reported an ectopic expression of neuropeptide-Y (NPY) immunoreactivity in messy fibres (MFs) in the contralateral hippocampus following a unilateral intrahippocampal (IH) injection of kainic acid (KA). In the present study we report that, in addition to MF NPY expression, unilateral IH KA injections also induce tolerance towards a subsequent intracerebroventricular (ICV) contralateral KA injection, resulting in a reduction in the number of overt seizures and degree of cell loss. (C) 1997 Elsevier Science Ireland Ltd.
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页码：135 / 139
页数：5
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