Pharmacokinetics of Itraconazole in Diabetic Rats

被引：4

作者：

Lee, Unji ^{[1
]}

Choi, Young H. ^{[2
,3
]}

Kim, So H. ^{[4
,5
]}

Lee, Byung K. ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[3] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[4] Kangnung Wonju Natl Univ, Dept Pharmacol, Coll Dent, Kangnung 210702, Kyunggi Do, South Korea

[5] Kangnung Wonju Natl Univ, Res Inst Oral Sci, Kangnung 210702, Kyunggi Do, South Korea

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 02期

关键词：

MELLITUS;

D O I：

10.1128/AAC.01145-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

After intravenous or oral administration of 10 mg/kg itraconazole to rats with streptozotocin-induced diabetes mellitus and to control rats, the total area under the plasma concentration-time curve from time 0 to 24 h (AUC(0-24)) for itraconazole and that for its metabolite, 7-hydroxyitraconazole, were similar between the two groups of rats. This may be explained by the comparable hepatic and intestinal intrinsic clearance rates for the disappearance of itraconazole and the formation of 7-hydroxyitraconazole in both groups of rats.

引用

页码：931 / 933

页数：3

共 13 条

[1] DETERMINATION OF ITRACONAZOLE IN SERUM WITH HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND FLUORESCENCE DETECTION [J].

ALLENMARK, S ;

EDEBO, A ;

LINDGREN, K .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 532 (01) :203-206

[2] CRITICAL EVALUATION OF THE POTENTIAL ERROR IN PHARMACOKINETIC STUDIES OF USING THE LINEAR TRAPEZOIDAL RULE METHOD FOR THE CALCULATION OF THE AREA UNDER THE PLASMA LEVEL TIME CURVE [J].

CHIOU, WL .

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1978, 6 (06) :539-546

[3] Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1 and 3A1/2 for the metabolism of metformin [J].

Choi, Y. H. ;

Lee, M. G. .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 149 (04) :424-430

[4]

DUGGLEBY RG, 1995, METHOD ENZYMOL, V249, P61

[5] Pharmacokinetics of theophylline in diabetes mellitus rats: Induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation [J].

Kim, YC ;

Lee, AK ;

Lee, JH ;

Lee, I ;

Lee, DC ;

Kim, SH ;

Kim, SG ;

Lee, MG .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2005, 26 (01) :114-123

[6] Telithromycin pharmacokinetics in rat model of diabetes mellitus induced by alloxan or streptozotocin [J].

Lee, Joo H. ;

Lee, Myung G. .

PHARMACEUTICAL RESEARCH, 2008, 25 (08) :1915-1924

[7]

Lee Y, 2009, B KOREAN CHEM SOC, V30, P107

[8]

LEWIS DFV, CYTOCHROME P450 STRU, P115

[9] Grapefruit juice decreases the systemic availability of itraconazole capsules in healthy volunteers [J].

Penzak, SR ;

Gubbins, PO ;

Gurley, BJ ;

Wang, PL ;

Saccente, M .

THERAPEUTIC DRUG MONITORING, 1999, 21 (03) :304-309

[10] CHANGES IN AMOUNTS OF CYTOCHROME-P450 ISOZYMES AND LEVELS OF CATALYTIC ACTIVITIES IN HEPATIC AND RENAL MICROSOMES OF RATS WITH STREPTOZOCIN-INDUCED DIABETES [J].

SHIMOJO, N ;

ISHIZAKI, T ;

IMAOKA, S ;

FUNAE, Y ;

FUJII, S ;

OKUDA, K .

BIOCHEMICAL PHARMACOLOGY, 1993, 46 (04) :621-627

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