Effect of machine perfusion preservation on delayed graft function in non-heart-beating donor kidneys early results

被引：36

作者：

Daemen, JHC ^{[1
]}

deVries, B ^{[1
]}

Oomen, APA ^{[1
]}

DeMeester, J ^{[1
]}

Kootstra, G ^{[1
]}

机构：

[1] UNIV HOSP,DEPT SURG,NL-6202 AZ MAASTRICHT,NETHERLANDS

来源：

TRANSPLANT INTERNATIONAL | 1997年 / 10卷 / 04期

关键词：

non-heart-beating donor; machine perfusion; kidney transplantation;

D O I：

10.1007/s001470050063

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The functioning of non-heart-beating (NHB) donor kidneys upon transplantation is often delayed. To evaluate the effect of preservation by machine perfusion (MP) on early post-transplant function, 37 NHB donor kidneys were compared to 74 matched heart-beating (HE) donor kidneys preserved by cold storage (CS). The NHB donor kidneys were subject to 49+/-34 min of warm ischemia. Delayed function (DF) and primary nonfunction (PNF) rates were significantly higher for NHB than for HE donor kidneys (49 % and 19 % vs 34 % and 7 %, respectively). Consequently, renal function was impaired but recovered within 6 months. MP could not eliminate the differences in DF rate between NHB and HE donor kidneys. However, NHB donor kidneys preserved by MP showed less DF than that reported in kidneys preserved by CS. This suggests that MP has a beneficial effect on ischemically damaged kidneys. The similar results observed with category 2 and category 3 NHB donors also suggest this effect. The high PNF rate emphasizes the need for viability tests that pre vent the transplantation of nonviable organs. We conclude that MP alone is not sufficient to reduce DF and PNF rates in NHB donor kidneys.

引用

页码：317 / 322

页数：6

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