Cytotoxic Acylphloroglucinol Derivatives from the Twigs of Garcinia cowa

被引：84

作者：

Xu, Gang ^{[2
]}

Kan, Winnie L. T. ^{[1
]}

Zhou, Yan ^{[2
]}

Song, Jing-Zheng ^{[2
]}

Han, Quan-Bin ^{[2
]}

Qiao, Chun-Feng ^{[2
]}

Cho, Chi-Hin ^{[1
]}

Rudd, John A. ^{[1
]}

Lin, Ge ^{[1
]}

Xu, Hong-Xi ^{[2
]}

机构：

[1] Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China

[2] Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Shatin, Hong Kong, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 02期

关键词：

INHIBITORY NATURAL-PRODUCTS; RADICAL REACTION-PRODUCTS; POLYISOPRENYLATED BENZOPHENONES; ANTIOXIDANT MECHANISM; GUIDED ISOLATION; XANTHONES; APOPTOSIS; BIOASSAY; GROWTH; FRUITS;

D O I：

10.1021/np9004147

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B-D, 2-4) and nine known analogues, wits isolated and characterized front the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.

引用

页码：104 / 108

页数：5

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