Ruthenium-catalyzed sequential reactions: Deracemization of secondary benzylic alcohols

被引：42

作者：

Shimada, Yusuke ^{[1
]}

Miyake, Yoshihiro ^{[1
]}

Matsuzawa, Hiroshi ^{[1
]}

Nishibayashi, Yoshiaki ^{[1
]}

机构：

[1] Univ Tokyo, Inst Engn Innovat, Bunkyo Ku, Tokyo 1138656, Japan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2007年 / 2卷 / 03期

关键词：

alcohols; homogeneous catalysis; oxidation; reduction; ruthenium;

D O I：

10.1002/asia.200600354

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The deracemization of secondary benzylic alcohols proceeds successfully by a two-step process with the appropriate combination of two different ruthenium complexes for catalysis in the first oxidation and second reduction steps. The sequential catalytic system provides a novel approach to obtaining optically active alcohols, including diols, in high yields with excellent enantioselectivity (up to 95% ee), in contrast to the conventional kinetic resolution of racemic alcohols.

引用

页码：393 / 396

页数：4

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